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| 1816 |
| | | Robert Finley, a US anti-slavery campaigner, founds the American Colonization Society to settle freed slaves in Africa | |
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| 1821 |
| | | The American Colonization Society buys the area later known as Liberia to settle freed slaves | |
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| 1822 |
| | | Mzilikazi, after a quarrel with Shaka, leads the Ndebele people to new territories west of Natal | |
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| 1822 |
| | | The first shipload of freed slaves reaches Cape Mesurado (in the region soon called Liberia) from the USA | |
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| c. 1830 |
| | | A network of undercover abolitionists in the southern states of America help slaves escape to freedom in the north | |
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| 1843 |
| | | The Great Migration across the north American continent to the Pacific establishes the Oregon Trail | |
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| c. 1846 |
| | | The Irish, fleeing from the potato famine at home, become the main group of immigrants to the USA | |
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| 1846 |
| | | Brigham Young leads the migration of Mormons west up the Missouri from Illinois | |
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| 1850 |
| | | As many as 50,000 US pioneers travel west this year on the Oregon Trail | |
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| 1851 |
| | | A journalist in the Terre Haute Express gives a piece of advice, 'Go west, young man', that chimes perfectly with the US pioneer spirit | |
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